Thermal Boost to Breast Tumor Bed—New Technique Description, Treatment Application and Example Clinical Results

Life

Artur J. Chyrek¹  Adam Chicheł¹  Wojciech Burchardt¹  Julian Malicki²  Grzegorz Zwierzchowski²  Grzegorz Bielęda²  Patrycja Stefaniak³ 

[1] Department of Brachytherapy, Greater Poland Cancer Center, 61-866 Poznan, Poland;Department of Electroradiology, Poznan University of Medical Sciences, 61-866 Poznan, Poland;Department of Medical Physics, Greater Poland Cancer Center, 61-866 Poznan, Poland;

关键词: thermal boost;    hyperthermia;    breast cancer;    interstitial brachytherapy;    treatment planning;   

DOI  :  10.3390/life12040512

来源: DOAJ

【 摘 要 】

(1) Current breast-conserving therapy for breast cancer consists of a combination of many consecutive treatment modalities. The most crucial goal of postoperative treatment is to eradicate potentially relapse-forming residual cancerous cells within the tumor bed. To achieve this, the HDR brachytherapy boost standardly added to external beam radiotherapy was enhanced with an initial thermal boost. This study presents an original thermal boost technique developed in the clinic. (2) A detailed point-by-point description of thermal boost application is presented. Data on proper patient selection, microwave thermal boost planning, and interstitial hyperthermia treatment delivery are supported by relevant figures and schemes. (3) Out of 1134 breast cancer patients who were administered HDR brachytherapy boost in the tumor bed, 262 were also pre-heated interstitially without unexpected complications. The results are supported by two example cases of hyperthermia planning and delivery. (4) Additional breast cancer interstitial thermal boost preceding HDR brachytherapy boost as a part of combined treatment in a unique postoperative setting was feasible, well-tolerated, completed in a reasonable amount of time, and reproducible. A commercially available interstitial hyperthermia system fit and worked well with standard interstitial brachytherapy equipment.

【 授权许可】

Unknown