Association of Gut Microbiome Dysbiosis with Neurodegeneration: Can Gut Microbe-Modifying Diet Prevent or Alleviate the Symptoms of Neurodegenerative Diseases?

Life

Delia Pei Shan Lee¹  Jung Eun Kim¹  Roger C. Ho²  Sangyong Jung³  Li Yang Tan³  Xin Yi Yeo³  Han-Gyu Bae⁴  Dong-Gyu Jo⁴ 

[1] Department of Food Science and Technology, Faculty of Science, National University of Singapore, Singapore 117542, Singapore;Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore;Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Singapore 138667, Singapore;School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea;

关键词: gut microbiome;    gut–brain axis;    neurodegenerative disease;    prebiotics foods;   

DOI  :  10.3390/life11070698

来源: DOAJ

【 摘 要 】

The central nervous system was classically perceived as anatomically and functionally independent from the other visceral organs. But in recent decades, compelling evidence has led the scientific community to place a greater emphasis on the role of gut microbes on the brain. Pathological observations and early gastrointestinal symptoms highlighted that gut dysbiosis likely precedes the onset of cognitive deficits in Alzheimer’s disease (AD) and Parkinson’s disease (PD) patients. The delicate balance in the number and functions of pathogenic microbes and alternative probiotic populations is critical in the modulation of systemic inflammation and neuronal health. However, there is limited success in restoring healthy microbial biodiversity in AD and PD patients with general probiotics interventions and fecal microbial therapies. Fortunately, the gut microflora is susceptible to long-term extrinsic influences such as lifestyle and dietary choices, providing opportunities for treatment through comparatively individual-specific control of human behavior. In this review, we examine the impact of restrictive diets on the gut microbiome populations associated with AD and PD. The overall evidence presented supports that gut dysbiosis is a plausible prelude to disease onset, and early dietary interventions are likely beneficial for the prevention and treatment of progressive neurodegenerative diseases.

【 授权许可】

Unknown