The Gut Microbiome in Schizophrenia and the Potential Benefits of Prebiotic and Probiotic Treatment

Nutrients

JonathanC. W. Liu¹  Ilona Gorbovskaya¹  MargaretK. Hahn¹  DanielJ. Müller¹ 

[1] Centre for Addiction and Mental Health, Campbell Family Mental Health Research Institute, Toronto, ON M5T 1R8, Canada;

关键词: gut microbiome;    gut–brain axis;    schizophrenia;    antipsychotics;    prebiotics;    probiotics;   

DOI  :  10.3390/nu13041152

来源: DOAJ

【 摘 要 】

The gut microbiome (GMB) plays an important role in developmental processes and has been implicated in the etiology of psychiatric disorders. However, the relationship between GMB and schizophrenia remains unclear. In this article, we review the existing evidence surrounding the gut microbiome in schizophrenia and the potential for antipsychotics to cause adverse metabolic events by altering the gut microbiome. We also evaluate the current evidence for the clinical use of probiotic and prebiotic treatment in schizophrenia. The current data on microbiome alteration in schizophrenia remain conflicting. Longitudinal and larger studies will help elucidate the confounding effect on the microbiome. Current studies help lay the groundwork for further investigations into the role of the GMB in the development, presentation, progression and potential treatment of schizophrenia.

【 授权许可】

Unknown