Recent Developments in the Area of Asymmetric Transfer Hydrogenation

Molecules

关键词: asymmetric;    transfer;    hydrogenation;    catalysis;    ruthenium;   

DOI  :  10.3390/50100004

来源: DOAJ

【 摘 要 】

The use of an enantiomerically pure amino alcohol, coupled to a transfer hydrogenation process, in the asymmetric catalysis of the reduction of ketones to alcohols, is described. The process works well for unfunctionalised ketones, affording e.e.s of up to 98%, and excellent conversions. We have recently extended, for the first time in this application, the scope of the methodology to the reductions of a-heteroatom substituted substrates, through the use of the appropriate protecting groups on each atom.

【 授权许可】

Unknown