New Epigenetic Pathway of Carcinogenesis Associated with Helicobacter Pylori

Gastroenterologìa

S.I. Klymniuk¹  E.M. Kovanova¹  M.S. Tvorko¹ 

[1] State Higher Educational Institution «Ternopil State Medical University named after I.Ya. Horbachevskyi of Ministry of Healthcare of Ukraine», Ternopil;

关键词: epigenetic;    genetic;    carcinogenesis;    oncogenes;    Helicobacter pylori;   

DOI  :  10.22141/2308-2097.3.57.2015.81534

来源: DOAJ

【 摘 要 】

New epigenetic pathway of Helicobacter pylori carcinogenesis is initiated by trigger oncogenes of the bacteria. The main mechanism of carcinogenesis — tyrosine kinase phosphorylation with excessive activation of tyrosine kinases and activation of MAPK ERK signaling pathways of normal cell proliferation, that disturbs normal proliferation and leads to uncontrolled cell growth, transformation and, as a result, to tumorigenesis.

【 授权许可】

Unknown