Quality of Prenatal and Childhood Diet Predicts Neurodevelopmental Outcomes among Children in Mexico City

Nutrients

AndreaA. Baccarelli¹  ManuelaA. Orjuela¹  StefanieA. Busgang²  Katherine Svensson²  AshleyJ. Malin²  RobertO. Wright²  Chris Gennings²  Emily Oken³  Ivan Pantic⁴  Lourdes Schnaas⁴  AlejandraJ. Cantoral⁵  MarthaM. Téllez-Rojo⁵ 

[1] Columbia Mailman School of Public Health, 722 W 168th Street, New York, NY 10032, USA;Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 17 East 102nd Street, New York, NY 10029, USA;Division of Chronic Disease Research across the Life course, Department of Population Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA;Instituto Nacional de Perinatología, Montes Urales 800, Lomas Virreyes, Ciudad de México C.P. 11000, Mexico;Instituto Nacional de Salud Pública, Avenida Universidad 655, Santa María Ahuacatitlán, Cuernavaca 62100, Mexico;

关键词: nutrition;    neurodevelopment;    micronutrients;    macronutrients;    nutrient mixtures;   

DOI  :  10.3390/nu10081093

来源: DOAJ

【 摘 要 】

Adequate nutrition is important for neurodevelopment. Although nutrients are ingested in combination, the impact of specific nutrients within the context of a nutrient mixture has not been studied with respect to health, such as neurodevelopment. Therefore, we examined the impact of prenatal and childhood nutrient mixtures on neurodevelopmental outcomes. Participants included mother–child pairs in the Programming Research in Obesity, Growth, Environment, and Social Stress (PROGRESS) prospective birth cohort in Mexico City. We assessed prenatal and child micro- and macronutrient profiles among 65 and 329 children, respectively, via food frequency questionnaires. Neurodevelopmental outcomes of 4–6 year-old children were measured using the McCarthy Scales of Children’s Abilities (MSCA). We conducted weighted quantile sum (WQS) regression analyses to calculate indices reflecting “good” and “poor” prenatal and childhood nutrition. After adjusting for maternal education, socioeconomic status, the Home Observation for Measurement of the Environment (HOME) score, and total caloric intake, the good prenatal and childhood nutrition indices predicted more favorable neurodevelopment, while both poor nutrition indices predicted poorer neurodevelopment. These associations were stronger in prenatal than childhood models. Monounsaturated fats predicted various neurodevelopmental abilities relatively strongly in both models. Prenatal and childhood consumption of combinations of beneficial nutrients may contribute to more favorable neurodevelopment.

【 授权许可】

Unknown