Don't forget arterial thrombosis in patients with COVID-19: A case series

Thrombosis Update

Ramzi Kurd¹  Sharon Einav²  Daniel D. Gold³ 

[1] Corresponding author. Emergency Department Shaare Zedek Medical Center Shmu'el Bait St. 12, Jerusalem, 9103102, Israel.;Department of Internal Medicine, Shaare Zedek Medical Center and Hebrew University, Faculty of Medicine, Jerusalem, Israel;Emergency Department, Shaare Zedek Medical Center and Hebrew University, Faculty of Medicine, Jerusalem, Israel;

关键词: COVID-19;    SARS COV-2;    Thromboembolism;    Arterial thrombosis;    Arterial occlusion;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: The acute disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS COV-2) is accompanied by a hypercoagulable state. Multiple publications have described the venous thromboembolic events associated with coronavirus disease 2019 (COVID-19) but arterial thromboembolic events have yet to be described. Cases description: We describe five COVID-19 patients that developed severe morbidity as a result of occlusive arterial thromboembolic events occurring despite treatment with low molecular weight heparin. All cases presented with an acute confusional state and were accompanied by rapid elevations of lactate and D-dimers and leukocytes. The end organs involved were the kidneys, spleen, liver, lungs, central nervous system, intestines and limbs. Only one of the five patients survived. Conclusion: COVID-19 is associated with not only venous but also arterial thromboembolic events. Further research is required to clarify the incidence, causes and possible modes of prevention of this potentially lethal disease complication.

【 授权许可】

Unknown