The use of posaconazole delayed-release tablets in the successful treatment of suspected mucormycosis in a bottlenose dolphin (Tursiops truncatus) calf

Medical Mycology Case Reports

Nuno U. Silva¹  Gonçalo N. Marques²  Carla A. Flanagan³  Miriam O. Leal³ 

[1] Zoomarine Portugal, N125 KM 65, 8201-864, Guia, Portugal;Corresponding author.;Zoomarine Portugal, N125 KM 65, 8201-864, Guia, Portugal;

关键词: Mucormycosis;    Cunninghamella bertholettiae;    Posaconazole;    Bottlenose dolphin;    Therapeutic drug monitoring;   

DOI  :  

来源: DOAJ

【 摘 要 】

Mucorales infections in cetaceans have a high mortality rate. This case report refers to a bottlenose dolphin calf with suspected mucormycosis treated with posaconazole. This antifungal agent was discontinued after 96 days of therapy, however, the infection relapsed. Posaconazole was then resumed for a total of 255 days, with no signs of disease reactivation. The retrospective analysis of posaconazole serum levels in this successful case showed concentrations varying between 5.18 and 11.63 mg/L.

【 授权许可】

Unknown