Disseminated Saksenaea infection in an immunocompromised host associated with a good clinical outcome: a case report and review of the literature

BMC Infectious Diseases

R. Baird¹  F. Foroughi¹  K. Campbell²  V. Tayal²  S. Lynar³  E. M. Meumann³  J. Davies³  N. Davidson⁴  L. C. Crawford⁵  S. E. Kidd⁵ 

[1] Department of Pathology, Royal Darwin Hospital, Darwin, Australia;Division of Medicine, Royal Darwin Hospital, Darwin, Australia;Division of Medicine, Royal Darwin Hospital, Darwin, Australia;Global and Tropical Health Division, Charles Darwin University, Menzies School of Health Research, Darwin, Australia;Division of Medicine, Royal Darwin Hospital, Darwin, Australia;Sullivan and Nicolaides Pathology, Brisbane, Australia;National Mycology Reference Centre, Microbiology and Infectious Diseases, SA Pathology, Frome Road, Adelaide, South Australia, Australia;

关键词: Mucormycosis;    Disseminated fungal infection;    Amphotericin B;    Posaconazole;   

DOI  :  10.1186/s12879-020-05459-9

来源: Springer

【 摘 要 】

BackgroundSaksenaea species (spp.) are uncommon causes of mucormycosis but are emerging pathogens mostly associated with trauma and soil contamination often in immunocompetent hosts. Due to lack of sporulation in the laboratory, diagnosis and susceptibility testing is difficult so optimal treatment regimens are unknown.Case presentationA 67 year-old man from the Northern Territory in Australia, with a history of eosinophilic granulomatosis with polyangiitis, developed disseminated Saksenaea infection after initially presenting with symptoms consistent with bacterial pyelonephritis. Despite a delay in diagnosis; with aggressive surgical management and dual therapy with amphotericin B and posaconazole, he survived.ConclusionsWe describe an unusual case of disseminated infection with a favourable outcome to date.

【 授权许可】

CC BY