Surface structure change properties: Auto-soft bionic fibrous membrane in reducing postoperative adhesion

Bioactive Materials

Yongfu Ma¹  Xiaoyu Liang¹  Jiangxue Li¹  Charles C. Han¹  Heran Wang²  Yang Liu³  Ruoqing Mao³  Tongshuo Zhang³  Zhenyu Lin³  Ying Liu⁴  Shanshan Xu⁵  Jipeng Jiang⁵  Shilin Li⁶  Chenhong Wang⁶ 

[1] CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China;State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, 730070, China;;CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety &Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, 100853, PR China;Institute for Advanced Study, Shenzhen University, Shenzhen, 518060, China;State Key Laboratory of Polymer Physics and Chemistry, Joint Laboratory of Polymer Science and Materials, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China;

关键词: Fibrous membrane;    Anti-adhesion;    Surface;    Electrospun;    Biocompatibility;   

DOI  :  

来源: DOAJ

【 摘 要 】

Peritoneal adhesion is the most common adverse effect following abdominal surgery or inflammation. The occurrence in clinical trials has been successfully reduced using barriers. However, the shortcomings of frequently used adhesion barriers, such as rapid degradation rate of gel barrier and inadequate operation ability of solid barrier, cannot be ignored. In this study, a fibrous membrane with an ECM-like structure was prepared. The adhesion properties were reduced significantly by changing the surface structure. The fibrous membrane caused less inflammatory response and much less peripheral adhesion and intestinal obstruction compared to the casting film and the commercial film with smooth surface, though with the same components. Because of the auto-soft bionic structure and similarity in the mechanical modulus of the tissues, the fibrous membrane was more flexible when it adhered to the tissues, showed excellent effectiveness and biocompatibility. In addition to the rat and miniature pig models, a randomized, placebo-controlled, and multicenter clinical pilot study with 150 patients confirmed that because of its flexibility, biodegradability, and similarity to mechanical modulus and structure with tissues involved, the fibrous membrane served as a favorable implant for preventing post-operation adhesion.

【 授权许可】

Unknown