Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans

Frontiers in Endocrinology

Adeyinka O. Laiyemo¹  Hassan Ashktorab¹  Komal Sodhi²  Alexandra Nichols²  Gail Nunlee-Bland³  Akbar Soleimani⁴  Hassan Brim⁵  Seyed Mehdi Nouraie⁶ 

[1] Department of Medicine, Cancer Center, College of Medicine, Washington, DC, United States;Department of Surgery and Pharmacology, Translational Research, Marshall University Joan Edwards School of Medicine, Huntington, WV, United States;Endocrinology Division, College of Medicine, Howard University, Washington, DC, United States;Islamic Azad University, Kashmar, Iran;Pathology Department, College of Medicine, Washington, DC, United States;University of Pittsburg, Medical Center, Pittsburg, PA, United States;

关键词: adiponectin;    leptin;    IGF-1;    tumor necrosis factor alpha;    biomarkers;    colorectal adenomas;   

DOI  :  10.3389/fendo.2018.00077

来源: DOAJ

【 摘 要 】

The potential role of adiponectin, leptin, IGF-1, and tumor necrosis factor alpha (TNF-α) as biomarkers in colorectal adenoma is not clear. Therefore, we aimed to investigate the blood serum levels of these biomarkers in colorectal adenoma. The case–control study consisted of serum from 180 African American patients with colon adenoma (cases) and 198 healthy African Americans (controls) at Howard University Hospital. We used ELISA for adiponectin, leptin, IGF-1, and TNF-α detection and quantification. Statistical analysis was performed by t-test and multivariate logistic regression. The respective differences in median leptin, adiponectin, IGF-1, and TNF-α levels between control and case groups (13.9 vs. 16.4), (11.3 vs. 46.0), (4.5 vs. 12.9), and (71.4 vs. 130.8) were statistically significant (P < 0.05). In a multivariate model, the odds ratio for adiponectin, TNF-α, and IGF-1 were 2.0 (95% CI = 1.6–2.5; P < 0.001), 1.5 (95% CI = 1.5(1.1–2.0); P = 0.004), and 1.6 (95% CI = 1.3–2.0; P < 0.001), respectively. There was a positive correlation between serum adiponectin and IGF-1 concentrations with age (r = 0.17, P < 0.001 and r = 0.13, P = 0.009), TNF-α, IGF-1, and leptin concentration with body mass index (BMI) (r = 0.44, P < 0.001; r = 0.11, P = 0.03; and r = 0.48, P < 0.001), respectively. Also, there was a negative correlation between adiponectin and leptin concentrations with BMI (r = −0.40, P < 0.001), respectively. These data support the hypothesis that adiponectin, IGF-1, and TNF-α high levels correlate with higher risk of colon adenoma and can thus be used for colorectal adenomas risk assessment.

【 授权许可】

Unknown