卷:60 | |
Enhanced nutrition improves growth and increases blood adiponectin concentrations in very low birth weight infants | |
Blakstad, Elin W. ; Moltu, Sissel J. ; Nakstad, Britt ; Veierod, Marit B. ; Strommen, Kenneth ; Juliusson, Petur B. ; Almaas, Astrid N. ; Ronnestad, Arild E. ; Braekke, Kristin ; Drevon, Christian A. ; Iversen, Per O. | |
Akershus Univ Hosp | |
关键词: premature; metabolic syndrome; leptin; adiponectin; IGF-1; | |
DOI : 10.3402/fnr.v60.33171 | |
学科分类:食品科学和技术 | |
【 摘 要 】
Background: Adequate nutrient supply is essential for optimal postnatal growth in very low birth weight (VLBW, birth weight < 1,500 g) infants. Early growth may influence the risk of metabolic syndrome later in life. Objective: To evaluate growth and blood metabolic markers (adiponectin, leptin, and insulin-like growth factor-1 (IGF-1)) in VLBW infants participating in a randomized nutritional intervention study. Design: Fifty VLBW infants were randomized to an enhanced nutrient supply or a standard nutrient supply. Thirty-seven infants were evaluated with growth measurements until 2 years corrected age (CA). Metabolic markers were measured at birth and 5 months CA. Results: Weight gain and head growth were different in the two groups from birth to 2 years CA (weight gain: p(interaction) = 0.006; head growth: p(interaction) = 0.002). The intervention group improved their growth z-scores after birth, whereas the control group had a pronounced decline, followed by an increase and caught up with the intervention group after discharge. At 5 months CA, adiponectin concentrations were higher in the intervention group and correlated with weight gain before term (r = 0.35) and nutrient supply (0.35 <= r <= 0.45). Leptin concentrations correlated with weight gain after term and IGF-1 concentrations with length growth before and after term and head growth after term (0.36 <= r <= 0.53). Conclusion: Enhanced nutrient supply improved early postnatal growth and may have prevented rapid catchup growth later in infancy. Adiponectin concentration at 5 months CA was higher in the intervention group and correlated positively with early weight gain and nutrient supply. Early nutrition and growth may affect metabolic markers in infancy.
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