Transcriptional Control of Metastasis by Integrated Stress Response Signaling

Frontiers in Oncology

Li-Xian Yang¹  Si Lu¹  Yu-Xiong Feng¹  Zi-Jian Cao¹  Jiang-Sha Zhao¹  Jia You² 

[1] Cancer Center, Zhejiang University, Hangzhou, China;School of Life Sciences, Westlake University, Hangzhou, China;Zhejiang Provincial Key Laboratory of Pancreatic Disease, First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China;

关键词: metastasis;    transcription;    integrated stress response (ISR);    cancer;    EMT;   

DOI  :  10.3389/fonc.2021.770843

来源: DOAJ

【 摘 要 】

As a central cellular program to sense and transduce stress signals, the integrated stress response (ISR) pathway has been implicated in cancer initiation and progression. Depending on the genetic mutation landscape, cellular context, and differentiation states, there are emerging pieces of evidence showing that blockage of the ISR can selectively and effectively shift the balance of cancer cells toward apoptosis, rendering the ISR a promising target in cancer therapy. Going beyond its pro-survival functions, the ISR can also influence metastasis, especially via proteostasis-independent mechanisms. In particular, ISR can modulate metastasis via transcriptional reprogramming, in the help of essential transcription factors. In this review, we summarized the current understandings of ISR in cancer metastasis from the perspective of transcriptional regulation.

【 授权许可】

Unknown