Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers

OncoImmunology

Judith Michels¹  Maria Castedo²  Juncheng Pan²  Adrien Joseph²  Guido Kroemer² 

[1] Gustave Roussy Cancer Campus;Université de Paris, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers;

关键词: tumor microenvironment;    immune escape;    metabolism;    vitamin b;    immunotherapy;    cd8+ t cells;    dendritic cells;    survival;    cervical cancer;    non-small cell lung cancer;   

DOI  :  10.1080/2162402X.2021.1950954

来源: DOAJ

【 摘 要 】

Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confers resistance to chemotherapy with cisplatin. Recently, we found that these prognostically adverse alterations in oncometabolism also correlate with the rarefaction of immune effectors in the tumor bed.

【 授权许可】

Unknown