Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NFκB Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells

International Journal of Molecular Sciences

Tomoko Goto¹  Shoko Sato¹  Hsin-Jung Ho¹  PuspoE. Giriwono¹  Hitoshi Shirakawa¹  Michio Komai¹  Yukihide Aoyama¹  Yusuke Ohsaki¹ 

[1] Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, 468-1 Aramaki Aza Aoba, Aoba-ku, Sendai 980-8572, Japan;

关键词: anti-inflammation;    geranylgeraniol;    IRAK1;    isoprenoid;    TRAF6;   

DOI  :  10.3390/ijms20092320

来源: DOAJ

【 摘 要 】

Geranylgeraniol (GGOH), a natural isoprenoid found in plants, has anti-inflammatory effects via inhibiting the activation of nuclear factor-kappa B (NFκB). However, its detailed mechanism has not yet been elucidated. Recent studies have revealed that isoprenoids can modulate signaling molecules in innate immune responses. We found that GGOH decreased the expression of lipopolysaccharide (LPS)-induced inflammatory genes in human macrophage-like THP-1 cells. Furthermore, we observed that the suppression of NFκB signaling proteins, in particular interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor receptor-associated factor 6 (TRAF6), occurred in GGOH-treated cells prior to LPS stimulation, suggesting an immunomodulatory effect. These results indicate that GGOH may modulate and help prevent excessive NFκB activation that can lead to numerous diseases.

【 授权许可】

Unknown