Early Chronic Kidney Disease (G1-G3a) in Combination with Steatosis as a Predictor of Incident Ischemic Heart Disease: A Longitudinal Study in Non-Diabetic Koreans

Biomedicines

Yong-Jae Lee¹  Byoung-Jin Park²  Dong-Hyuk Jung²  Sung-Bum Lee³ 

[1] Department of Family Medicine, Gangnam Severance Hospital, Seoul 06273, Korea;Department of Family Medicine, Yongin Severance Hospital, Yongin-si 16995, Korea;Department of Health Check-up, Yongin Severance Hospital, Yongin-si 16995, Korea;

关键词: chronic kidney disease;    hepatic steatosis;    longitudinal study;    ischemic heart disease;   

DOI  :  10.3390/biomedicines9101358

来源: DOAJ

【 摘 要 】

Hepatic steatosis and chronic kidney disease (CKD) in the advanced stages are closely related to cardiovascular diseases. Despite the potential connection between early CKD (G1-G3a) and hepatic steatosis on cardiometabolic risks, few studies have revealed their causal link to ischemic heart disease (IHD). We prospectively investigated the combined effect of CKD in earlier stages and hepatic steatosis on incident IHD risk in large-scale, non-diabetic Koreans. Data were assessed from 16,531 participants without diabetes from the Health Risk Assessment Study (HERAS) and Korea Health Insurance Review and Assessment (HIRA) data. We divided the study population into four groups according to the existence of early CKD and hepatic steatosis: controls, early CKD only, hepatic steatosis only, and both early CKD and hepatic steatosis. We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional-hazard regression models over a 50-month period. During the follow-up period, 326 (2.0%) patients developed IHD. HRs of IHD in the four groups were 1.00 (controls), 1.26 (95% CI 0.72–2.19), 1.19 (95% CI 0.90–1.57) and 1.76 (95% CI 1.04–2.97), respectively, after adjusting for potential confounding variables. Even less than stage 3A, CKD could precede and predict IHD in patients with hepatic steatosis.

【 授权许可】

Unknown