Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis

Green Chemistry Letters and Reviews

Beatriz G. de la Torre¹  Anamika Sharma¹  Ashish Kumar¹  Fernando Albericio¹ 

[1] University of KwaZulu-Natal;

关键词: fluorenylmethoxycarbonyl (fmoc);    green solvent;    peptide;    polystyrene resin;    supported chemistry;   

DOI  :  10.1080/17518253.2021.1965663

来源: DOAJ

【 摘 要 】

PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives. It can also swell polystyrene and ChemMatrix, the two resins most widely used in solid-phase peptide synthesis. The synthesis of model peptides has been carried out, rendering the target peptide as a major component. The performance of PolarClean demonstrates its utility in the toolbox for Green Solid-Phase Peptide Synthesis.

【 授权许可】

Unknown