Rhodiasolv PolarClean – a greener alternative in solid-phase peptide synthesis

Green Chemistry Letters and Reviews

Beatriz G. de la Torre¹  Fernando Albericio²  Ashish Kumar³  Anamika Sharma³ 

[1] KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Afric;Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Afric;CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, and Department of Organic Chemistry, University of Barcelona, Barcelona, Spai;Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spai;Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Afric;KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Afric;

关键词: Fluorenylmethoxycarbonyl (Fmoc);    Green solvent;    peptide;    polystyrene resin;    supported chemistry;   

DOI  :  10.1080/17518253.2021.1965663

来源: Taylor & Francis

【 摘 要 】

PolarClean, a green solvent prepared through the valorization of a byproduct of Nylon-66 manufacturing, shows an excellent capacity to dissolve all Fmoc-amino acids and key coupling reagents and additives. It can also swell polystyrene and ChemMatrix, the two resins most widely used in solid-phase peptide synthesis. The synthesis of model peptides has been carried out, rendering the target peptide as a major component. The performance of PolarClean demonstrates its utility in the toolbox for Green Solid-Phase Peptide Synthesis.

【 授权许可】

CC BY