Enhanced oral bioavailability of nisoldipine-piperine-loaded poly-lactic-co-glycolic acid nanoparticles

Nanotechnology Reviews

Kamboj Anjoo¹  Sidhu Shabir²  Rathee Permender³ 

[1] Chandigarh College of Pharmacy, Landran, Punjab, India;Department of Food Engineering, IKG Punjab Technical University, Kapurthala, Punjab, India;Department of RIC, IKG Punjab Technical University, Kapurthala, Punjab, India;

关键词: bioenhancer;    cyp3a4;    nisoldipine;    optimization;    piperine;    plga;   

DOI  :  10.1515/ntrev-2017-0151

来源: DOAJ

【 摘 要 】

Piperine helps in the improvement of bioavailability through pharmacokinetic interaction by modulating metabolism when administered with other drugs. Nisoldipine is a substrate for cytochrome P4503A4 enzymes. The study was undertaken to assess the influence of piperine on the pharmacokinetics and pharmacodynamics of nisoldipine nanoparticles in rats.

【 授权许可】

Unknown