期刊论文详细信息
Nanotechnology Reviews
Enhanced oral bioavailability of nisoldipine-piperine-loaded poly-lactic-co-glycolic acid nanoparticles
Kamboj Anjoo1  Sidhu Shabir2  Rathee Permender3 
[1] Chandigarh College of Pharmacy, Landran, Punjab, India;Department of Food Engineering, IKG Punjab Technical University, Kapurthala, Punjab, India;Department of RIC, IKG Punjab Technical University, Kapurthala, Punjab, India;
关键词: bioenhancer;    cyp3a4;    nisoldipine;    optimization;    piperine;    plga;   
DOI  :  10.1515/ntrev-2017-0151
来源: DOAJ
【 摘 要 】

Piperine helps in the improvement of bioavailability through pharmacokinetic interaction by modulating metabolism when administered with other drugs. Nisoldipine is a substrate for cytochrome P4503A4 enzymes. The study was undertaken to assess the influence of piperine on the pharmacokinetics and pharmacodynamics of nisoldipine nanoparticles in rats.

【 授权许可】

Unknown   

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