Grapefruit Seed Extract as a Natural Derived Antibacterial Substance against Multidrug-Resistant Bacteria

Antibiotics

Jin-Hwan Kwak¹  Tae-Su Jang²  Hee-Won Han³  Hae-Won Kim³  Hae-Hyoung Lee³  Jung-Hwan Lee³  JonathanCampbell Knowles³ 

[1] Department of Life Science, Handong Global University, 558 Handong-ro, Pohang, Gyeongsangbuk-do 37554, Korea;Department of Pre-Medi, College of Medicine, Dankook University, 119 Dandae-ro, Cheonan, Chungcheongnam-do 31116, Korea;Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Chungcheongnam-do 31116, Korea;

关键词: multidrug-resistant bacteria;    nosocomial infection;    plant extract;    grapefruit seed extract;    antibacterial activity;   

DOI  :  10.3390/antibiotics10010085

来源: DOAJ

【 摘 要 】

Multidrug-resistant (MDR) bacteria are increasing due to the abuse and misuse of antibiotics, and nosocomial infections by MDR bacteria are also increasing. The aim of this study was to identify new substances that can target MDR bacteria among 12 plant extracts that are known to have antibacterial effects. The experiments were performed by the disk diffusion test and microdilution minimum inhibitory concentration (MIC) test, as described by the Clinical and Laboratory Standards Institute (CLSI). By screening against methicillin-sensitive Staphylococcus aureus (MSSA), grapefruit seed extract (GSE) was selected from 12 plant extracts for subsequent experiments. GSE showed antibacterial effects against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) in the disk diffusion test. Even at the lowest concentration, GSE showed antibacterial activity in the microdilution MIC test. As a result, we can conclude that GSE is a naturally derived antibacterial substance that exhibits a favorable antibacterial effect even at a very low concentration, so it is a good candidate for a natural substance that can be used to prevent or reduce nosocomial infections as coating for materials used in medical contexts or by mixing a small amount with other materials.

【 授权许可】

Unknown