Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments

Microbial Cell Factories

Margherita Sosio¹  Stefano Donadio¹  Marianna Iorio¹  Wenqing Chen²  Meng Zhang²  Liyuan Kong²  Rong Gong²  Zixin Deng² 

[1]

[2]Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan University

关键词: Natural product;    C-nucleoside antibiotics;    Biosynthesis;    Genome mining;    Synthetic biology;   

DOI  :  10.1186/s12934-021-01722-z

来源: DOAJ

【 摘 要 】

Abstract Epidemic diseases and antibiotic resistance are urgent threats to global health, and human is confronted with an unprecedented dilemma to conquer them by expediting development of new natural product related drugs. C-nucleoside antibiotics, a remarkable group of microbial natural products with diverse biological activities, feature a heterocycle base linked with a ribosyl moiety via an unusual C-glycosidic bond, and have played significant roles in healthcare and for plant protection. Elucidating how nature biosynthesizes such a group of antibiotics has provided the basis for engineered biosynthesis as well as targeted genome mining of more C-nucleoside antibiotics towards improved properties. In this review, we mainly summarize the recent advances on the biosynthesis of C-nucleoside antibiotics, and we also tentatively discuss the future developments on rationally accessing C-nucleoside diversities in a more efficient and economical way via synthetic biology strategies.

【 授权许可】

Unknown