Biosynthesis of C-nucleoside antibiotics in actinobacteria: recent advances and future developments

Microbial Cell Factories

Liyuan Kong¹  Wenqing Chen¹  Meng Zhang¹  Rong Gong¹  Zixin Deng²  Margherita Sosio³  Marianna Iorio³  Stefano Donadio³ 

[1]Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China

[2]Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, and School of Pharmaceutical Sciences, Wuhan University, 430071, Wuhan, China

[3]State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 200240, Shanghai, China

[4]Viale Ortles 22/4, 20139, Naicons Srl, Milan, Italy

关键词: Natural product;    C;    Biosynthesis;    Genome mining;    Synthetic biology;   

DOI  :  10.1186/s12934-021-01722-z

来源: Springer

【 摘 要 】

Epidemic diseases and antibiotic resistance are urgent threats to global health, and human is confronted with an unprecedented dilemma to conquer them by expediting development of new natural product related drugs. C-nucleoside antibiotics, a remarkable group of microbial natural products with diverse biological activities, feature a heterocycle base linked with a ribosyl moiety via an unusual C-glycosidic bond, and have played significant roles in healthcare and for plant protection. Elucidating how nature biosynthesizes such a group of antibiotics has provided the basis for engineered biosynthesis as well as targeted genome mining of more C-nucleoside antibiotics towards improved properties. In this review, we mainly summarize the recent advances on the biosynthesis of C-nucleoside antibiotics, and we also tentatively discuss the future developments on rationally accessing C-nucleoside diversities in a more efficient and economical way via synthetic biology strategies.

【 授权许可】

CC BY