Effect of Squid Cartilage Chitosan Molecular Structure on the Properties of Its Monofilament as an Absorbable Surgical Suture

Polymers

Jiaying Li¹  Wenqian Qin¹  Muhammad Shahid Riaz Rajoka¹  Wenjing Deng¹  Yiguang Wu¹  Yongxin Tan¹  Liqing Zhao¹  Zekai Ke²  Hafiza Mahreen Mehwish³ 

[1] Department of Food Science and Engineering, College of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen 518060, China;Department of Orthopaedics, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen 518060, China;Department of Pharmacy, Health Science Center, Shenzhen University, Shenzhen 518060, China;

关键词: squid cartilage chitosan;    absorbable surgical suture;    wet spinning;    degree of deacetylation;    viscosity average molecular weight;   

DOI  :  10.3390/polym14071306

来源: DOAJ

【 摘 要 】

Suture is an important part of surgery, and wounds closing after surgery remains a challenge for postoperative care. Currently, silk, linen fiber, and cotton are available in the market as non-absorbable suture biomaterials. So, there is an urgent need to develop a novel suture with advantageous characteristics compared to the ones available on the market. In present study, a series of ultra-high molecular weight chitosan with different DD and M_V were prepared from squid cartilage by alkaline treatment and ultrasonic degradation. The corresponding chitosan monofilaments were prepared by a wet spinning process and were characterized as sutures. The effects of the DD and M_V of chitosan on the properties of its monofilament were studied, including surface morphology, mechanical property, swelling ratio, ash content, in vitro enzymatic degradation, and in vitro cytotoxicity. According to the results, AS-85 was chosen to be the best suitable as an absorbable surgical suture, which was spun from squid cartilage chitosan with DD~85% and M_V~1.2 × 10⁶. The outcome of the present study might derive tremendous possibilities for the utilization of squid cartilage β-chitin for biomedical applications.

【 授权许可】

Unknown