Dynamic of plasmodium falciparum chloroquine resistance transporter gene Pfcrt K76T mutation five years after withdrawal of chloroquine in Burkina Faso

The Pan African Medical Journal

Odile Zampa¹  Tinga Robert Guiguemde¹  Halidou Tinto²  Innocent Valea²  Zekiba Tarnagda²  Karim Derra²  Paul Sondo²  Hermann Sorgho²  Seydou Diallo Nakanabo²  Adama Kazienga²  Jean-Bosco Ouedraogo² 

[1] Center Muraz of Bobo-Dioulasso, Burkina Faso;IRSS, Clinical Research Unit of Nanoro, CMA Saint Camille de Nanoro, Ouagadougou CMS 11, Burkina Faso;

关键词: malaria;    plasmodium falciparum;    chloroquine resistance;    pfcrt;   

DOI  :  10.11604/pamj.2015.21.101.6437

来源: DOAJ

【 摘 要 】

We investigated the evolution of Pfcrt K76T mutation five years after the withdrawal of chloroquine in Burkina Faso. A total of 675 clinical isolates collected from October 2010 to September 2012 were successfully genotyped. Single nucleotide polymorphism in Pfcrt(codon 76) gene was analyzed. The prevalence of resistant Pfcrt 76T allele was 20.55%. There was a progressive decrease of the proportion of mutant type pfcrt T76 from 2010 to 2012 (X2=5.508 p=0.0189). Our results suggest a progressive return of the wild type Pfcrt K76 in Burkina Faso but the prevalence of the mutants Pfcrt T76 still remains high.

【 授权许可】

Unknown