Preparation and Characterization of a Glycyrrhizic Acid-Based Drug Delivery System for Allergen-Specific Immunotherapy

Nanomaterials

Maria Bykova¹  Mikhail Khvostov²  Aleksandr Dushkin³  Veronika Evseenko³  Maxim Zelikman³  Ekaterina Pashkina⁴  Vladimir Kozlov⁴  Alina Aktanova⁴  Natalya Dumchenko⁵ 

[1] Department of Medicine, Novosibirsk State University, 2, Pirogova Street, 630090 Novosibirsk, Russia;Institute of Organic Chemistry SB RAS, 9, Lavrentev Prospect, 630090 Novosibirsk, Russia;Institute of Solid State Chemistry and Mechanochemistry, 18, Kutateladze, 630090 Novosibirsk, Russia;Research Institute of Fundamental and Clinical Immunology, 14, Yadrintsevskaya, 6300099 Novosibirsk, Russia;State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Novosibirsk Oblast, Russia;

关键词: glycyrrhizic acid;    house dust mite;    allergen-specific immunotherapy;    drug delivery;   

DOI  :  10.3390/nano12010148

来源: DOAJ

【 摘 要 】

The most effective method of treating allergic diseases, aimed not at relieving symptoms, but at eliminating the cause of the disease, is allergen-specific immunotherapy (AIT). To reduce the risk of side effects and improve the delivery of allergens to the mucosa, various delivery systems, such as liposomes, dendrimers, nanoparticles, etc., can be used. To date, there are data on the creation of delivery systems based on glycyrrhizic acid (GA) and its derivatives, but such a delivery system has not been used for allergen-specific therapy until now. It is also known that GA has an anti-inflammatory effect, shifts the balance towards Th1, and increases the number of Treg cells, meaning that it could potentially enhance the anti-allergic effect of AIT and reduce the risk of unwanted side effects. Thus, the study of the immunomodulatory effect of the supramolecular complexes (micelles) of GA with extracts of allergens holds promise for the development of new drugs for AIT.

【 授权许可】

Unknown