New Insights into the Role of Sphingolipid Metabolism in Melanoma

Cells

Bruno Ségui¹  Anne Montfort¹  Carine Dufau¹  Thierry Levade¹  Lorry Carrié¹  Mathieu Virazels¹  Nathalie Andrieu-Abadie¹ 

[1] Université Fédérale de Toulouse Midi-Pyrénées, Université Toulouse III Paul-Sabatier, Inserm 1037, Centre de Recherches en Cancérologie de Toulouse, Equipe Labellisée Fondation ARC, 2 avenue Hubert Curien, CS 53717, 31037 Toulouse CEDEX 1, France;

关键词: cancer;    ceramide;    gangliosides;    immunotherapy;    metastasis;    phenotype switching;   

DOI  :  10.3390/cells9091967

来源: DOAJ

【 摘 要 】

Cutaneous melanoma is a deadly skin cancer whose aggressiveness is directly linked to its metastatic potency. Despite remarkable breakthroughs in term of treatments with the emergence of targeted therapy and immunotherapy, the prognosis for metastatic patients remains uncertain mainly because of resistances. Better understanding the mechanisms responsible for melanoma progression is therefore essential to uncover new therapeutic targets. Interestingly, the sphingolipid metabolism is dysregulated in melanoma and is associated with melanoma progression and resistance to treatment. This review summarises the impact of the sphingolipid metabolism on melanoma from the initiation to metastatic dissemination with emphasis on melanoma plasticity, immune responses and resistance to treatments.

【 授权许可】

Unknown