Study for Evaluation of Hydrogels after the Incorporation of Liposomes Embedded with Caffeic Acid

Pharmaceuticals

Ioana Viorica Olariu¹  Ana Maria Muț¹  Georgeta Hermina Coneac¹  Lavinia Lia Vlaia¹  Ioana Lavinia Dejeu²  Anca Salomea Bodea²  Tunde Jurca³  Octavian Adrian Maghiar³  Eleonora Marian³  Annamaria Pallag³  Laura Grațiela Vicaș³  Mariana Eugenia Mureșan³  George Emanuiel Dejeu³ 

[1] Department II—Pharmaceutical Technology, Formulation and Technology of Drugs Research Center, “Victor Babeș” University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timișoara, Romania;Doctoral School of Biomedical Science, University of Oradea, 1 University Street, 410087 Oradea, Romania;Faculty of Medicine and Pharmacy, University of Oradea, 1 Decembrie Street, 410073 Oradea, Romania;

关键词: caffeic acid;    liposomes;    hydrogels;    carbopol;    rheological properties;   

DOI  :  10.3390/ph15020175

来源: DOAJ

【 摘 要 】

Caffeic acid (CA), a phenolic acid, is a powerful antioxidant with proven effectiveness. CA instability gives it limited use, so encapsulation in polymeric nanomaterials has been used to solve the problem but also to obtain topical hydrogel formulas. Two different formulas of caffeic acid liposomes were incorporated into three different formulas of carbopol-based hydrogels. A Franz diffusion cell system was used to evaluate the release of CA from hydrogels. For the viscoelastic measurements of the hydrogels, the equilibrium flow test was used. The dynamic tests were examined at rest by three oscillating tests: the amplitude test, the frequency test and the flow and recovery test. These carbopol gels have a high elasticity at flow stress even at very low polymer concentrations. In the analysis of the texture, the increase of the polymer concentration from 0.5% to 1% determined a linear increase of the values of the textural parameters for hydrogels. The textural properties of 1% carbopol-based hydrogels were slightly affected by the addition of liposomal vesicle dispersion and the firmness and shear work increased with increasing carbomer concentration.

【 授权许可】

Unknown