Iron-Catalysed C(sp2)-H Borylation Enabled by Carboxylate Activation

Molecules

Luke Britton¹  StephenP. Thomas¹  JamieH. Docherty¹  AndrewP. Dominey² 

[1] EaStCHEM School of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh EH9 3FJ, UK;GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK;

关键词: catalysis;    borylation;    iron;    c-h functionalisation;    pinacolborane;    photochemistry;   

DOI  :  10.3390/molecules25040905

来源: DOAJ

【 摘 要 】

Arene C(sp²)-H bond borylation reactions provide rapid and efficient routes to synthetically versatile boronic esters. While iridium catalysts are well established for this reaction, the discovery and development of methods using Earth-abundant alternatives is limited to just a few examples. Applying an in situ catalyst activation method using air-stable and easily handed reagents, the iron-catalysed C(sp²)-H borylation reactions of furans and thiophenes under blue light irradiation have been developed. Key reaction intermediates have been prepared and characterised, and suggest two mechanistic pathways are in action involving both C-H metallation and the formation of an iron boryl species.

【 授权许可】

Unknown