Potential Fluid Biomarkers for the Diagnosis of Mild Cognitive Impairment

International Journal of Molecular Sciences

Eva Bagyinszky¹  VoVan Giau¹  SeongSoo A. An¹ 

[1] Department of BionanoTechnology, Gachon University, 1342 Sungnam Daero, Sungnamsi 13120, Korea;

关键词: mild cognitive impairment;    Alzheimer’s disease;    biomarkers;    diagnosis;   

DOI  :  10.3390/ijms20174149

来源: DOAJ

【 摘 要 】

Mild cognitive impairment (MCI) is characterized by a level of cognitive impairment that is lower than normal for a person’s age, but a higher function than that that observed in a demented person. MCI represents a transitional state between normal aging and dementia disorders, especially Alzheimer’s disease (AD). Much effort has been made towards determining the prognosis of a person with MCI who will convert to AD. It is now clear that cerebrospinal fluid (CSF) levels of Aβ40, Aβ42, total tau and phosphorylated tau are useful for predicting the risk of progression from MCI to AD. This review highlights the advantages of the current blood-based biomarkers in MCI, and discusses some of these challenges, with an emphasis on recent studies to provide an overview of the current state of MCI.

【 授权许可】

Unknown