ConvDip: A Convolutional Neural Network for Better EEG Source Imaging

Frontiers in Neuroscience

Lukas Hecker²  Ludger Tebartz Van Elst³  Jürgen Kornmeier⁴  Rebekka Rupprecht⁵ 

[1] Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center, Freiburg, Germany;Faculty of Biology, University of Freiburg, Freiburg, Germany;Faculty of Medicine, University of Freiburg, Freiburg, Germany;Institute for Frontier Areas of Psychology and Mental Health (IGPP), Freiburg, Germany;Machine Learning Lab, University of Freiburg, Freiburg, Germany;

关键词: EEG-electroencephalogram;    artificial neural networks;    convolutional neural networks (CNN);    inverse problem;    machine learning;    electrical source imaging;   

DOI  :  10.3389/fnins.2021.569918

来源: DOAJ

【 摘 要 】

The electroencephalography (EEG) is a well-established non-invasive method in neuroscientific research and clinical diagnostics. It provides a high temporal but low spatial resolution of brain activity. To gain insight about the spatial dynamics of the EEG, one has to solve the inverse problem, i.e., finding the neural sources that give rise to the recorded EEG activity. The inverse problem is ill-posed, which means that more than one configuration of neural sources can evoke one and the same distribution of EEG activity on the scalp. Artificial neural networks have been previously used successfully to find either one or two dipole sources. These approaches, however, have never solved the inverse problem in a distributed dipole model with more than two dipole sources. We present ConvDip, a novel convolutional neural network (CNN) architecture, that solves the EEG inverse problem in a distributed dipole model based on simulated EEG data. We show that (1) ConvDip learned to produce inverse solutions from a single time point of EEG data and (2) outperforms state-of-the-art methods on all focused performance measures. (3) It is more flexible when dealing with varying number of sources, produces less ghost sources and misses less real sources than the comparison methods. It produces plausible inverse solutions for real EEG recordings from human participants. (4) The trained network needs <40 ms for a single prediction. Our results qualify ConvDip as an efficient and easy-to-apply novel method for source localization in EEG data, with high relevance for clinical applications, e.g., in epileptology and real-time applications.

【 授权许可】

Unknown