A fiber optic–nanophotonic approach to the detection of antibodies and viral particles of COVID-19

Nanophotonics

Scully Steven¹  Poor Vincent²  Belousov Vsevolod³  Mogford Jon⁴  Rajil Navid⁵  Han Zehua⁵  Agarwal Girish⁵  Adams Garry⁵  Zubairy Suhail⁵  Neuman Benjamin⁵  Zheltikov Aleksei⁵  Chapin Kimberly⁵  Esmaeili Shahriar⁵  Kattawar George⁵  Fernández-González Alma⁵  Sokolov Alexei⁵  Hemmer Philip⁵  Lee Ming-Che⁵  Verhoef Aart⁵  Wang Kai⁵  Cirillo Jeffrey⁵  Peng Tao⁵  Kim Moochan⁵  Svidzinsky Anatoly⁵  Deckert Volker⁵  Scully Marlan⁵  Delfan Sahar⁵  Fry Edward⁵  Brick Robert⁵  Yi Zhenhuan⁵  Suckewer Szymon⁵  Shih Yanhua⁶  Pan Jian-Wei⁷  Lu Chao-Yang⁷  Yang Lan⁸  Wang Dawei⁹  Zhu Shiyao⁹ 

[1] Collins Aerospace, Richardson, TX75082, USA;Princeton University, Princeton, NJ08544, USA;Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow117997, Russia;Texas A&M University System, College Station, TX77840, USA;Texas A&M University, College Station, TX77843, USA;University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD21250, USA;University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China;Washington University, St. Louis, MO63130, USA;Zhejiang University, 38 Zheda Rd, Hangzhou, 310027, P. R. China;

关键词: detection of sar-cov-2 virus;    hollow-core fibers;    laser spectroscopic technique;    nanophotonics;   

DOI  :  10.1515/nanoph-2020-0357

来源: DOAJ

【 摘 要 】

Dr. Deborah Birx, the White House Coronavirus Task Force coordinator, told NBC News on “Meet the Press” that “[T]he U.S. needs a ‘breakthrough’ in coronavirus testing to help screen Americans and get a more accurate picture of the virus’ spread.” We have been involved with biopathogen detection since the 2001 anthrax attacks and were the first to detect anthrax in real-time. A variation on the laser spectroscopic techniques we developed for the rapid detection of anthrax can be applied to detect the Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2 virus). In addition to detecting a single virus, this technique allows us to read its surface protein structure. In particular, we have been conducting research based on a variety of quantum optical approaches aimed at improving our ability to detect Corona Virus Disease-2019 (COVID-19) viral infection. Indeed, the detection of a small concentration of antibodies, after an infection has passed, is a challenging problem. Likewise, the early detection of disease, even before a detectible antibody population has been established, is very important. Our team is researching both aspects of this problem. The paper is written to stimulate the interest of both physical and biological scientists in this important problem. It is thus written as a combination of tutorial (review) and future work (preview). We join Prof. Federico Capasso and Editor Dennis Couwenberg in expressing our appreciation to all those working so heroically on all aspects of the COVID-19 problem. And we thank Drs. Capasso and Couwenberg for their invitation to write this paper.

【 授权许可】

Unknown