A fiber optic–nanophotonic approach to the detection of antibodies and viral particles of COVID-19

Nanophotonics

article

Navid Rajil¹  Volker Deckert¹  Sahar Delfan¹  Shahriar Esmaeili¹  Alma Fernández-González¹  Edward Fry¹  Zehua Han¹  Philip Hemmer¹  George Kattawar¹  Moochan Kim¹  Alexei Sokolov¹  Ming-Che Lee¹  Chao-Yang Lu⁵  Jon Mogford⁶  Benjamin Neuman¹  Jian-Wei Pan⁵  Tao Peng¹  Vincent Poor⁷  Steven Scully⁸  Yanhua Shih⁹  Szymon Suckewer¹  Zhenhuan Yi¹  Anatoly Svidzinsky¹  Aart Verhoef¹  Dawei Wang^1,10  Kai Wang¹  Lan Yang^1,11  Aleksei Zheltikov¹  Shiyao Zhu^1,10  Suhail Zubairy¹  Marlan Scully¹  Garry Adams¹  Girish Agarwal¹  Vsevolod Belousov^1,15  Robert Brick¹  Kimberly Chapin¹  Jeffrey Cirillo¹ 

[1] Texas A&M University, College Station;Leibniz Institute of Photonic Technology;Friedrich Schiller University;Zavoisky Physical-Technical Institute;University of Science and Technology of China;Texas A&M University System, College Station;Princeton University;Collins Aerospace;University of Maryland;Zhejiang University;Washington University;International Laser Center, Moscow State University;Russian Quantum Center;Baylor University;Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences;Pirogov Russian National Research Medical University;Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency

关键词: detection of SAR-CoV-2 virus;    hollow-core fibers;    laser spectroscopic technique;    nanophotonics;   

DOI  :  10.1515/nanoph-2020-0357

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Dr. Deborah Birx, the White House Coronavirus Task Force coordinator, told NBC News on “Meet the Press” that “[T]he U.S. needs a ‘breakthrough’ in coronavirus testing to help screen Americans and get a more accurate picture of the virus’ spread.” We have been involved with biopathogen detection since the 2001 anthrax attacks and were the first to detect anthrax in real-time. A variation on the laser spectroscopic techniques we developed for the rapid detection of anthrax can be applied to detect the Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2 virus). In addition to detecting a single virus, this technique allows us to read its surface protein structure. In particular, we have been conducting research based on a variety of quantum optical approaches aimed at improving our ability to detect Corona Virus Disease-2019 (COVID-19) viral infection. Indeed, the detection of a small concentration of antibodies, after an infection has passed, is a challenging problem. Likewise, the early detection of disease, even before a detectible antibody population has been established, is very important. Our team is researching both aspects of this problem. The paper is written to stimulate the interest of both physical and biological scientists in this important problem. It is thus written as a combination of tutorial (review) and future work (preview). We join Prof. Federico Capasso and Editor Dennis Couwenberg in expressing our appreciation to all those working so heroically on all aspects of the COVID-19 problem. And we thank Drs. Capasso and Couwenberg for their invitation to write this paper.

【 授权许可】

CC BY