Povidone-Iodine Demonstrates Rapid In Vitro Virucidal Activity Against SARS-CoV-2, The Virus Causing COVID-19 Disease

Infectious Diseases and Therapy

Maren Eggers¹  Timothy M. Jenkins²  Harsha Arumugam³  Abhishek Ananthanarayanan³  Yacine Hadjiat³  Adrian Eng Zheng Kang⁴  Velraj Sivalingam⁴  Danielle E. Anderson⁴ 

[1] Labor Prof. Dr. G. Enders MVZ GbR;Mundipharma Research Limited;Mundipharma Singapore Holding Pte. Limited;Programme in Emerging Infectious Diseases, Duke-NUS Medical School;

关键词: Anti-infective agents;    COVID-19;    Povidone-iodine;    PVP-I;    SARS-CoV-2;    Upper respiratory tract infections;   

DOI  :  10.1007/s40121-020-00316-3

来源: DOAJ

【 摘 要 】

Abstract Introduction As of 22 June 2020, Severe Acute Respiratory Syndrome (SARS)-coronavirus (CoV)-2 has infected more than 8.95 million people worldwide, causing > 468,000 deaths. The virus is transmitted through respiratory droplets and physical contact from contaminated surfaces to the mucosa. Hand hygiene and oral decontamination among other measures are key to preventing the spread of the virus. We report the in vitro virucidal activity of topical and oral povidone-iodine (PVP-I) products against SARS-CoV-2. Methods Suspension assays were used to assess the virucidal activity of PVP-I against SARS-CoV-2. Products were tested at a contact time of 30 s for virucidal activity. Viral titres were calculated using the Spearman–Kärber method and reported as median tissue culture infectious dose (TCID50)/mL. Results All four products [antiseptic solution (PVP-I 10%), skin cleanser (PVP-I 7.5%), gargle and mouth wash (PVP-I 1%) and throat spray (PVP-I 0.45%)] achieved ≥ 99.99% virucidal activity against SARS-CoV-2, corresponding to ≥ 4 log10 reduction of virus titre, within 30 s of contact. Conclusion This study provides evidence of rapid and effective virucidal activity of PVP-I against SARS-CoV-2. PVP-I-based products are widely available for medical and personal use for hand hygiene and oral decontamination, and could be readily integrated into coronavirus disease, COVID-19, infection control measures in hospital and community settings.

【 授权许可】

Unknown