Topological, Mechanical and Biological Properties of Ti6Al4V Scaffolds for Bone Tissue Regeneration Fabricated with Reused Powders via Electron Beam Melting

Materials

Paolo Mengucci¹  MariaLaura Gatto¹  Lorenzo Fassina²  Riccardo Groppo³  Luca Iuliano⁴  Manuela Galati⁴  Livia Visai⁵  Nora Bloise⁵ 

[1] Department SIMAU, Università Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy;Department of Electrical, Computer and Biomedical Engineering, Centre for Health Technologies (CHT), University of Pavia, Via Ferrata 5, 27100 Pavia, Italy;Department of Engineering “Enzo Ferrari”, Università di Modena e Reggio Emilia, 41121 Modena, Italy;Department of Management and Production Engineering (DIGEP), Politecnico di Torino, 10129 Torino, Italy;Department of Molecular Medicine, Centre for Health Technologies (CHT), INSTM UdR of Pavia, University of Pavia, 27100 Pavia, Italy;

关键词: titanium implants;    additive manufacturing;    reused powder;    unit cell topology;    tissue engineering;    mechanical properties;   

DOI  :  10.3390/ma14010224

来源: DOAJ

【 摘 要 】

Cellularized scaffold is emerging as the preferred solution for tissue regeneration and restoration of damaged functionalities. However, the high cost of preclinical studies creates a gap between investigation and the device market for the biomedical industry. In this work, bone-tailored scaffolds based on the Ti6Al4V alloy manufactured by electron beam melting (EBM) technology with reused powder were investigated, aiming to overcome issues connected to the high cost of preclinical studies. Two different elementary unit cell scaffold geometries, namely diamond (DO) and rhombic dodecahedron (RD), were adopted, while surface functionalization was performed by coating scaffolds with single layers of polycaprolactone (PCL) or with mixture of polycaprolactone and 20 wt.% hydroxyapatite (PCL/HA). The mechanical and biological performances of the produced scaffolds were investigated, and the results were compared to software simulation and experimental evidence available in literature. Good mechanical properties and a favorable environment for cell growth were obtained for all combinations of scaffold geometry and surface functionalization. In conclusion, powder recycling provides a viable practice for the biomedical industry to strongly reduce preclinical costs without altering biomechanical performance.

【 授权许可】

Unknown