Studies on the development of spectrophotometric method for the determination of haloperidol in pharmaceutical preparations

Química Nova

Nafisur Rahman¹  Habibur Rahman¹  Asma Khatoon¹ 

[1] Aligarh Muslim University;

关键词: haloperidol;    ion-pair complex;    spectrophotometry;   

DOI  :  10.1590/S0100-40422012000200028

来源: DOAJ

【 摘 要 】

A spectrophotometric method based on the formation of ion-pair complex between haloperidol and eriochrome black T (EBT) at pH 1.85 has been described. The formed complex was extracted quantitatively into chloroform and measured at 510 nm. Infra red (IR) studies were performed to confirm the formation of ion-pair complex. Beer's law was obeyed in the concentration range of 2.0-9.0 µg mL-1 with molar absorptivity of 2.67 × 10(4) L mol-1 cm-1. The detection limit was found to be 0.18 µg mL-1. Statistical comparison of the results of the proposed method with those of the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.

【 授权许可】

Unknown