Role of type I interferons in inflammasome activation, cell death and disease during microbial infection

Frontiers in Cellular and Infection Microbiology

Thirumala-Devi eKanneganti¹  R. K. Subbarao eMalireddi¹ 

[1] St. Jude Children's Research Hospital;

关键词: Cell Death;    Inflammasome;    caspase-1;    NLR;    type I IFN;    IFNβ;   

DOI  :  10.3389/fcimb.2013.00077

来源: DOAJ

【 摘 要 】

Interferons were discovered over a half-century ago as antiviral factors. The role of type I interferons (IFNs) has been studied in the pathogenesis of both acute and chronic microbial infections. Deregulated type I IFN production results in a damaging cascade of cell death, inflammation and immunological host responses that can lead to tissue injury and disease progression. Here, we summarize the role of type I IFNs in the regulation of cell death and disease during different microbial infections, ranging from viruses and bacteria to fungal pathogens. Understanding the specific mechanisms driving type I IFN-mediated cell death and disease could aid in the development of targeted therapies.

【 授权许可】

Unknown