Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment

Acta Pharmaceutica Sinica B

Jian Ding¹  Qin Xie²  Yi Chen³ 

[1] Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310012, China;Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China;

关键词: CD8+ T lymphocyte;    Stromal cell;    Tumor microenvironment;    Immunosuppression;    Immunotherapy;    Antitumor;   

DOI  :  

来源: DOAJ

【 摘 要 】

CD8+ T lymphocytes are pivotal cells in the host response to antitumor immunity. Tumor-driven microenvironments provide the conditions necessary for regulating infiltrating CD8+ T cells in favor of tumor survival, including weakening CD8+ T cell activation, driving tumor cells to impair immune attack, and recruiting other cells to reprogram the immune milieu. Also in tumor microenvironment, stromal cells exert immunosuppressive skills to avoid CD8+ T cell cytotoxicity. In this review, we explore the universal function and fate decision of infiltrated CD8+ T cells and highlight their antitumor response within various stromal architectures in the process of confronting neoantigen-specific tumor cells. Thus, this review provides a foundation for the development of antitumor therapy based on CD8+ T lymphocyte manipulation.

【 授权许可】

Unknown