Tumor-associated macrophages in cholangiocarcinoma: complex interplay and potential therapeutic target

EBioMedicine

Yong Ma¹  Hongchi Jiang²  Menghua Zhou³  Yanan Xu³  Zihao Li³  Chaoqun Wang³  Shounan Lu³ 

[1] Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of Hepatic Minimal Invasive Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China;Corresponding authors.;Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of Hepatic Minimal Invasive Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China;

关键词: Tumor-associated macrophages;    Cholangiocarcinoma;    Tumor microenvironment;    Tumor-promotion;    Immunosuppression;    Targeted therapy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Cholangiocarcinoma (CCA) is an aggressive and multifactorial malignancy of the biliary tract. The carcinogenesis of CCA is associated with genomic and epigenetic abnormalities, as well as environmental effects. However, early clinical diagnosis and reliable treatment strategies of CCA remain unsatisfactory. Multiple compartments of the tumor microenvironment significantly affect the progression of CCA. Tumor-associated macrophages (TAMs) are a type of plastic immune cells that are recruited and activated in the CCA microenvironment, especially at the tumor invasive front and perivascular sites. TAMs create a favorable environment that benefits CCA growth by closely interacting with CCA cells and other stromal cells via releasing multiple protumor factors. In addition, TAMs exert immunosuppressive and antichemotherapeutic effects, thus intensifying the malignancy. Targeting TAMs may provide an improved understanding of, and novel therapeutic approaches for, CCA. This review focuses on revealing the interplay between TAMs and CCA.

【 授权许可】

Unknown