White matter microstructure disruption in early stage amyloid pathology

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Philip Scheltens¹  Pieter Jelle Visser¹  Jori Tomassen¹  Carole Sudre¹  Elles Konijnenberg¹  Dennis Van ‘t Ent²  Kristine E. Stickney²  Anouk Den Braber²  Lyduine E. Collij³  Herwin Top³  Mara ten Kate³  Isadora Lopes Alves³  Frederik Barkhof³  Viktor Wottschel³  Silvia Ingala³  Maqsood M. Yaqub³  Alle Meije Wink³  Bart N.M. vanBerckel³ 

[1] Alzheimer Center Amsterdam UMC, Location VUmc Amsterdam The Netherlands;Dept. of Biological Psychology VU University Amsterdam Amsterdam The Netherlands;Dept. of Radiology and Nuclear Medicine Amsterdam UMC, Location VUmc Amsterdam The Netherlands;

关键词: Amyloid beta (Aβ);    diffusion tensor imaging (DTI);    magnetic resonance imaging (MRI);    positron emission tomography (PET);    preclinical Alzheimer's disease (AD);    white matter microstructure;   

DOI  :  10.1002/dad2.12124

来源: DOAJ

【 摘 要 】

Abstract Introduction Amyloid beta (Aβ) accumulation is the first pathological hallmark of Alzheimer's disease (AD), and it is associated with altered white matter (WM) microstructure. We aimed to investigate this relationship at a regional level in a cognitively unimpaired cohort. Methods We included 179 individuals from the European Medical Information Framework for AD (EMIF‐AD) preclinAD study, who underwent diffusion magnetic resonance (MR) to determine tract‐level fractional anisotropy (FA); mean, radial, and axial diffusivity (MD/RD/AxD); and dynamic [18F]flutemetamol) positron emission tomography (PET) imaging to assess amyloid burden. Results Regression analyses showed a non‐linear relationship between regional amyloid burden and WM microstructure. Low amyloid burden was associated with increased FA and decreased MD/RD/AxD, followed by decreased FA and increased MD/RD/AxD upon higher amyloid burden. The strongest association was observed between amyloid burden in the precuneus and body of the corpus callosum (CC) FA and diffusivity (MD/RD) measures. In addition, amyloid burden in the anterior cingulate cortex strongly related to AxD and RD measures in the genu CC. Discussion Early amyloid deposition is associated with changes in WM microstructure. The non‐linear relationship might reflect multiple stages of axonal damage.

【 授权许可】

Unknown