Interspecies Interactions Between Streptococcus Mutans and Streptococcus Agalactiae in vitro

Frontiers in Cellular and Infection Microbiology

Wenyuan Shi¹  Xuesong He¹  Ruiqi Yang²  Lihong Guo²  Jianwei Liu²  Xianjun Lu²  Tingjun Liu²  Jia Liu² 

[1] Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, United States;Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China;Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China;The Forsyth Institute, Cambridge, MA, United States;

关键词: group B Streptococcus;    coaggregation;    Streptococcus mutans;    interspecies interactions;    Streptococcus agalactiae;   

DOI  :  10.3389/fcimb.2020.00344

来源: DOAJ

【 摘 要 】

Streptococcus mutans is an oral species closely associated with dental caries. As an early oral colonizer, S. mutans utilizes interspecies coaggregation to promote the colonization of subsequent species and affect polymicrobial pathogenesis. Previous studies have confirmed several adhering partner species of S. mutans, including Candida albicans and Fusobacterium nucleatum. In this study, we discovered new intergeneric co-adherence between S. mutans and the saliva isolate Streptococcus agalactiae (GBS-SI101). Research shows that GBS typically colonizes the human gastrointestinal and vaginal tracts. It is responsible for adverse pregnancy outcomes and life-threatening infections in neonates and immunocompromised people. Our results revealed that GtfB and GtfC of S. mutans, which contributed to extracellular polysaccharide synthesis, promoted coaggregation of S. mutans with GBS-SI101. In addition, oral streptococci, including Streptococcus sanguinis, Streptococcus gordonii and S. mutans, barely inhibited the growth of GBS-SI101. This study indicated that S. mutans could help GBS integrate into the Streptococcus-associated oral polymicrobial community and become a resident species in the oral cavity, increasing the risk of oral infections.

【 授权许可】

Unknown