Assessment of the Macular Microvasculature in High Myopes With Swept Source Optical Coherence Tomographic Angiography

Frontiers in Medicine

Seang-Mei Saw²  Marcus Ang²  Chee-Wai Wong²  Rupesh Agrawal²  Hla Myint Htoon²  Shoun Tan³  Colin S. Tan³  Yee-Ling Wong⁴  Saiko Matsumura⁶  Charumati Sabanayagam⁶ 

[1] D Vision Sciences Asia, Middle East, Russia and Africa (AMERA), Essilor International, Singapore, Singapore;Duke-NUS Medical School, Singapore, Singapore;National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore;;R&Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore;Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore;

关键词: high myopia;    swept source OCT angiography;    macular microvasculature;    foveal avascular zone;    macular vessel density;   

DOI  :  10.3389/fmed.2021.619767

来源: DOAJ

【 摘 要 】

Background: The risk of pathologic myopia (PM) increases with worsening myopia and may be related to retinal microvasculature alterations. To evaluate this, we analyzed the macular microvasculature of myopes with swept source-optical coherence tomographic angiography (SS-OCTA) in adolescent and young adult Singaporeans.Methods: This is a prevalent case-control study including 93 young Chinese from the Strabismus, Amblyopia and Refractive error in Singaporean children (STARS, N = 45) study and the Singapore Cohort Study of Risk Factors for Myopia (SCORM, N = 48) studies. Macular vessel density (VD) measurements were obtained from 3 × 3 mm SS-OCTA scans and independently assessed using ImageJ. These measurements were compared between individuals with non-high myopia [non-HM, N = 40; SE >-5.0 diopter (D)] and HM (SE ≤-5.0D, N = 53).Results: The mean macular VD was 40.9 ± 0.6% and 38.2 ± 0.5% in the non-HM and HM, groups, respectively (p = 0.01 adjusted for age and gender). Mean FAZ area in the superficial layer was 0.22 ± 0.02 mm2 in the HM group, which was smaller compared to non-HM group (0.32 ± 0.03 mm2, p = 0.04). Mean deep FAZ area was similar between the two groups (0.45 ± 0.03 mm2 and 0.48 ± 0.04 mm2 in the HM and non-HM groups, respectively, p = 0.70).Conclusions: VD was lower and superficial FAZ area was smaller, in adolescents and young adults with HM compared to non-HM. These findings require validation in prospective studies to assess their impact on the subsequent development of PM.

【 授权许可】

Unknown