Assessment of the Macular Microvasculature in High Myopes With Swept Source Optical Coherence Tomographic Angiography

Frontiers in Medicine

article

Chee-Wai Wong¹  Seang-Mei Saw¹  Saiko Matsumura¹  Hla Myint Htoon¹  Shoun Tan⁴  Colin S. Tan¹  Marcus Ang¹  Yee-Ling Wong¹  Rupesh Agrawal¹  Charumati Sabanayagam¹ 

[1] Singapore National Eye Centre, Singapore Eye Research Institute;Duke-NUS Medical School;Saw Swee Hock School of Public Health, National University of Singapore;National Healthcare Group Eye Institute, Tan Tock Seng Hospital;R&D Vision Sciences Asia

关键词: high myopia;    swept source OCT angiography;    macular microvasculature;    foveal avascular zone;    macular vessel density;   

DOI  :  10.3389/fmed.2021.619767

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Background: The risk of pathologic myopia (PM) increases with worsening myopia and may be related to retinal microvasculature alterations. To evaluate this, we analyzed the macular microvasculature of myopes with swept source-optical coherence tomographic angiography (SS-OCTA) in adolescent and young adult Singaporeans. Methods: This is a prevalent case-control study including 93 young Chinese from the Strabismus, Amblyopia and Refractive error in Singaporean children (STARS, N = 45) study and the Singapore Cohort Study of Risk Factors for Myopia (SCORM, N = 48) studies. Macular vessel density (VD) measurements were obtained from 3 × 3 mm SS-OCTA scans and independently assessed using ImageJ. These measurements were compared between individuals with non-high myopia [non-HM, N = 40; SE >-5.0 diopter (D)] and HM (SE ≤-5.0D, N = 53). Results: The mean macular VD was 40.9 ± 0.6% and 38.2 ± 0.5% in the non-HM and HM, groups, respectively ( p = 0.01 adjusted for age and gender). Mean FAZ area in the superficial layer was 0.22 ± 0.02 mm 2 in the HM group, which was smaller compared to non-HM group (0.32 ± 0.03 mm 2 , p = 0.04). Mean deep FAZ area was similar between the two groups (0.45 ± 0.03 mm 2 and 0.48 ± 0.04 mm 2 in the HM and non-HM groups, respectively, p = 0.70). Conclusions: VD was lower and superficial FAZ area was smaller, in adolescents and young adults with HM compared to non-HM. These findings require validation in prospective studies to assess their impact on the subsequent development of PM.

【 授权许可】

CC BY