期刊论文详细信息
Frontiers in Neuroscience
Resting-State Functional Magnetic Resonance Imaging and Functional Connectivity Density Mapping in Patients With Optic Neuritis
Ke Song1  Ya-Li Lv2  Ting Su3  Yi Shao4  Si-Yi Chen4  Yong Wang5  Jiao Li5  Mei-Xia Ren5 
[1] Department of Equipment, Xi’an People’s Hospital, Xi’an Fourth Hospital, Xi’an, China;Department of Neurology, Xi’an People’s Hospital, Xi’an Fourth Hospital, Xi’an, China;Department of Ophthalmology, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, United States;Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, China;Department of Ophthalmology, Xi’an People’s Hospital, Xi’an Fourth Hospital, Xi’an, China;Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University, Medical College of Xiamen University, Xiamen, China;
关键词: resting-state functional connectivity;    brain activities;    optic neuritis;    functional connectivity density;    functional magnetic resonance imaging;   
DOI  :  10.3389/fnins.2021.718973
来源: DOAJ
【 摘 要 】

Background: Using resting-state functional connectivity (rsFC), we investigated alternations in spontaneous brain activities reflected by functional connectivity density (FCD) in patients with optic neuritis (ON).Methods: We enrolled 28 patients with ON (18 males, 10 females) and 24 healthy controls (HCs; 16 males, 8 females). All subjects underwent functional magnetic resonance imaging (fMRI) in a quiet state to determine the values of rsFC, long-range FCD (longFCD), and short-range FCD (IFCD). Receiver operating characteristic (ROC) curves were generated to distinguish patients from HCs.Results: The ON group exhibited obviously lower longFCD values in the left inferior frontal gyrus triangle, the right precuneus and the right anterior cingulate, and paracingulate gyri/median cingulate and paracingulate gyri. The left median cingulate and paracingulate gyri and supplementary motor area (SMA) were also significantly lower. Obviously reduced IFCD values were observed in the left middle temporal gyrus/angular gyrus/SMA and right cuneus/SMA compared with HCs.Conclusion: Abnormal neural activities were found in specific brain regions in patients with ON. Specifically, they showed significant changes in rsFC, longFCD, and IFCD values. These may be useful to identify the specific mechanism of change in brain function in ON.

【 授权许可】

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