Altered Functional Connectivity Density in Subtypes of Parkinson’s Disease

Frontiers in Human Neuroscience

Xiaomei Jiang¹  Jing Li²  Yanling Zhang²  Jiuquan Zhang³  Xiaofei Hu³  Jian Wang³  Minglong Liang³  Cheng Luo⁴  Yuchao Jiang⁴  Dezhong Yao⁴ 

[1] Department of Centre for Disease Prevention and Control, Chengdu Military RegionChengdu, China;Department of Neurology, Southwest Hospital, Third Military Medical UniversityChongqing, China;Department of Radiology, Southwest Hospital, Third Military Medical UniversityChongqing, China;Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of ChinaChengdu, China;

关键词: Parkinson’s disease;    subtypes;    resting state;    fMRI;    functional connectivity density;   

DOI  :  10.3389/fnhum.2017.00458

来源: DOAJ

【 摘 要 】

Parkinson’s disease (PD) can be classified into tremor-dominant and akinetic-rigid subtypes, each of which exhibits a unique clinical course and prognosis. The neural basis for these disparate manifestations is not well-understood, however. This study comprehensively investigated the altered functional connectivity patterns of these two subtypes. Twenty-five tremor-dominant patients, 25 akinetic-rigid patients and 26 normal control subjects participated in this study. Resting-state functional MRI data were analyzed using functional connectivity density (FCD) and seed-based functional connectivity approaches. Correlations between neuroimaging measures and clinical variables were also calculated. Compared with normal control, increased global FCD occurred most extensively in frontal lobe and cerebellum in both subtypes. Compared with akinetic-rigid patients, the tremor-dominant patients showed significantly increased global FCD in the cerebellum and decreased global FCD in portions of the bilateral frontal lobe. Furthermore, different subtypes demonstrated different cerebello-cortical functional connectivity patterns. Moreover, the identified FCD and functional connectivity correlated significantly with clinical variables in the PD patients, and particularly the FCD indices distinguished the different subtypes with high sensitivity (95%) and specificity (80%). These findings indicate that the functional connectivity patterns in the cerebellum and frontal lobe are altered in both subtypes of PD, especially cerebellum are highly related to tremor.

【 授权许可】

Unknown