Evaluation of laboratory markers of progression of HIV disease to death

Revista da Sociedade Brasileira de Medicina Tropical

José Roberto Binda Júnior¹  Érica Milena Fernandes Rabelo²  Alessandro Carvalho dos Santos²  Rodrigo Artur Souza de Oliveira²  João Arnaud Diniz Neto²  Onildo Martins Santos Júnior²  Aila de Menezes Ferreira²  Graça Maria de Castro Viana²  Maria do Desterro Soares Brandão Nascimento²  Carolina de Souza Galvão² 

[1] Universidade CEUMA;Universidade Federal do Maranhão;

关键词: Fatores de risco;    Prognóstico;    HIV/AIDS;   

DOI  :  10.1590/s0037-86822011005000062

来源: DOAJ

【 摘 要 】

INTRODUCTION: One of the important current problems in HIV/AIDS infection is the establishment of epidemiological and laboratorial prognostic parameters during patient follow-up. This study aimed at analyzing the evolution of laboratory tests: CD4 lymphocyte count, viral load, hemoglobin (Hb), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and the epidemiological variables sex and age as prognostic factors for survival in progression to death among AIDS patients. METHODS: A retrospective study was conducted using analysis of medical records, and prospective 24-month follow-up of patients with HIV/ AIDS attended at the President Vargas Hospital Outpatient Clinic, a reference center in HIV/ AIDS attendance in the State of Maranhão, Brazil. The study analyzed patients aged 10 to 60 years old, who manifested AIDS and who were not using antiretroviral therapy or had used it for less than 5 years. The Chi-square test was used for statistical analysis. RESULTS: The sample included 100 patients - 57 were current outpatients, and 43 had died. The variables viral load (p=0.726), ALT (p=0.314), sex (p=0.687), and age (p=0.742) were analyzed, and no evidence of association between them and worst prognosis was observed. CONCLUSIONS: A significant relation was verified between low Hb levels (p=0.000) and CD4 (p=0.000) and shorter survival.

【 授权许可】

Unknown