Blood Clotting Decreases Pulmonary Circulation during the Coronavirus Disease

Mathematics

Anass Bouchnita¹  Anastasia Mozokhina²  Vitaly Volpert² 

[1] Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA;SM Nikolsky Mathematical Institute, People’s Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia;

关键词: COVID-19;    lung inflammation;    blood clotting;    pulmonary blood circulation;    mathematical model;   

DOI  :  10.3390/math9192401

来源: DOAJ

【 摘 要 】

Spontaneous blood clotting in pulmonary circulation caused by thrombo-inflammation is one of the main mortality causes during the COVID-19 disease. Blood clotting leads to reduced pulmonary circulation and blood oxygenation. Lung inflammation can be evaluated with noninvasive diagnostic techniques. However, the correlation of the severity of the inflammation with the pulmonary blood flow has not been established. To address this question, in this work, we develop a multiscale model taking into account the interaction of a local model of thrombus growth with 1D hemodynamics in a vessel network. Flux reduction depending on the level of lung obstruction is evaluated. In particular, the model obtains that an obstruction level of 5% leads to a 12% reduction of blood flux. The suggested approach can be used to investigate the interaction of blood clotting and flow not only in the pulmonary network but also in other complex vessel networks.

【 授权许可】

Unknown