Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students

Genes

Magdalena Dzitkowska-Zabielska¹  Aleksandra Bojarczuk¹  Paweł Cięszczyk¹  Ewelina Maculewicz²  Andrzej Mastalerz²  Łukasz Dziuda³  Oktawiusz Antkowiak⁴  Bożena Antkowiak⁴  Myosotis Massidda⁵  Aleksandra Garbacz⁶ 

[1] Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland;Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-809 Warsaw, Poland;Military Institute of Aviation Medicine, 01-755 Warszawa, Poland;Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland;Sport and Exercise Sciences Degree Courses, Faculty of Medicine and Surgery, University of Cagliari, 09100 Cagliari, Italy;Warsaw University of Life Sciences—SGGW, 02-787 Warsaw, Poland;

关键词: Interleukin;    IL10;    IL10RB;    genetic polymorphisms;    haplotype;    BMI;   

DOI  :  10.3390/genes13020291

来源: DOAJ

【 摘 要 】

Background: To date, nearly 300 single-nucleotide polymorphisms (SNPs) associated with BMI, waist-to-hip ratio, and other adiposity traits have been identified by GWAS. With regards to IL10, at least 49 IL10-associated polymorphisms have been reported. However, little is known regarding the relationship between SNPs of the IL10 gene and the risk of obesity in young men. The aim of the present study was to investigate the relationship between SNPs of the IL10 and IL10RB genes and the risk of obesity in young men. Methods: A cohort of 139 male students were enrolled and the following IL10 and IL10RB SNPs were analyzed: IL10 (rs1518110), IL10 (rs3024491), IL10RB (rs2834167). The subjects were divided into groups depending on obesity parameters: body mass index (BMI), fat mass index (FMI) and fat percentage (Fat%). Statistical analysis was conducted for a single locus and haplotypes, an association between SNPs and body composition parameters was tested with four genetic models: dominant, recessive, codominant and overdominant mode of inheritance (MOI). Results: Significant association was found for interaction IL10 (rs1518110) × IL10RB (rs2834167) with Fat% value exceeding 20 in codominant (p-value = 0.03, OR = 0.34, 95% CI 0.08 1.44) and dominant model (p-value = 0.03, OR = 0.34, 95% CI 0.08 1.44) Conclusion: Our study shows for the first time that there is a correlation between the occurrence of specific polymorphisms of IL10 gene (rs1518110, rs3024491 and rs2834167) and the possibility of obesity.

【 授权许可】

Unknown