Substantial Overview on Mesenchymal Stem Cell Biological and Physical Properties as an Opportunity in Translational Medicine

International Journal of Molecular Sciences

Alessandra Pelagalli¹  Heba Abdelrazik²  Emanuele Giordano³  Elena De Falco⁴  Cristiana Griffoni⁵  Giovanni Barbanti Brodano⁵ 

[1] Department of Advanced Biomedical Sciences, University of Naples “Federico II”, 80131 Naples, Italy;Department of Clinical Pathology, Cairo University, Cairo 1137, Egypt;Department of Electrical, Electronic and Information Engineering “Guglielmo Marconi” (DEI), University of Bologna, 47522 Cesena, Italy;Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy;Department of Oncological and Degenerative Spine Surgery, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy;

关键词: mesenchymal stem cells (msc);    translational medicine;    angiogenesis;    immune modulation;    bone regeneration;    3d scaffolds;    biomaterials;   

DOI  :  10.3390/ijms20215386

来源: DOAJ

【 摘 要 】

Mesenchymal stem cells (MSC) have piqued worldwide interest for their extensive potential to treat a large array of clinical indications, their unique and controversial immunogenic and immune modulatory properties allowing ample discussions and debates for their possible applications. Emerging data demonstrating that the interaction of biomaterials and physical cues with MSC can guide their differentiation into specific cell lineages also provide new interesting insights for further MSC manipulation in different clinical applications. Moreover, recent discoveries of some regulatory molecules and signaling pathways in MSC niche that may regulate cell fate to distinct lineage herald breakthroughs in regenerative medicine. Although the advancement and success in the MSC field had led to an enormous increase in the amount of ongoing clinical trials, we still lack defined clinical therapeutic protocols. This review will explore the exciting opportunities offered by human and animal MSC, describing relevant biological properties of these cells in the light of the novel emerging evidence mentioned above while addressing the limitations and challenges MSC are still facing.

【 授权许可】

Unknown