Epidermal stem cells in wound healing and their clinical applications

Stem Cell Research & Therapy

Kun Xiong¹  Julin Xie²  Jingru Wang³  Xiaodong Chen³  Ronghua Yang³  Fengxia Liu⁴ 

[1] Department of Anatomy and Neurobiology, School of Basic Medical Science, Morphological Sciences Building, Central South University;Department of Burn Surgery, First Affiliated Hospital of Sun Yat-Sen University;Department of Burn Surgery, The First People’s Hospital of Foshan;Department of Human Anatomy, School of Basic Medical Science, Xinjiang Medical University;

关键词: Epidermal stem cells;    Wound healing;    Signaling pathway;    Epithelial regeneration;   

DOI  :  10.1186/s13287-019-1312-z

来源: DOAJ

【 摘 要 】

Abstract The skin has important barrier, sensory, and immune functions, contributing to the health and integrity of the organism. Extensive skin injuries that threaten the entire organism require immediate and effective treatment. Wound healing is a natural response, but in severe conditions, such as burns and diabetes, this process is insufficient to achieve effective treatment. Epidermal stem cells (EPSCs) are a multipotent cell type and are committed to the formation and differentiation of the functional epidermis. As the contributions of EPSCs in wound healing and tissue regeneration have been increasingly attracting the attention of researchers, a rising number of therapies based on EPSCs are currently under development. In this paper, we review the characteristics of EPSCs and the mechanisms underlying their functions during wound healing. Applications of EPSCs are also discussed to determine the potential and feasibility of using EPSCs clinically in wound healing.

【 授权许可】

Unknown