Albumen Glue, New Material for Conjunctival Graft Surgery, an Animal Experiment

11th Joint Conference on Chemistry in Conjunction with the 4th Regional Biomaterials Scientific Meeting

材料科学;化学;生物科学

Kartiwa, A.^1 ; Miraprahesti, R.^1 ; Sovani, I.^1 ; Enus, S.^1 ; Boediono, A.^2

Ophthalmology Department, Medical Faculty, Padjadjaran University, Bandung, Indonesia^1

Anatomy, Physiology and Pharmacology Department, Veterinary Faculty, Bogor Agricultural University, Bogor, Indonesia^2

关键词: 10 minutes;    Animal experiments;    Experimental animals;    Fibrin glue;    Mann-Whitney;    Wound healing;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/172/1/012003/pdf
DOI  :  10.1088/1757-899X/172/1/012003

来源: IOP

【 摘 要 】

Attach conjunctival graft commonly used are suture technique and fibrin glue. This study was to investigate albumen glue as an alternative to suture technique in attaching conjunctival graft in rabbits. Aim of this study was to compare the conjunctival wound healing between albumen glue and suture technique in rabbit eye as a model. There was an experimental animal study included 32 eyes (16 rabbits) in PT. Bio Farma (Persero) and Histology Laboratory, Faculty of Medicine, Padjadjaran University from March 2014 to July 2104. The study consisted of albumen glue group and suture technique group. The examination included the comparison of conjunctival graft attachment and histologic examination by microscopically was done to obtain the wound gap, then analyze by Mann-Whitney test. The results indicated that the graft attachment was significantly better-using albumen glue (grade 4) compared to suture (grade 2-3) on day-1 after surgery (p=0,000). The wound gap was smaller using albumen glue (0-0,33 μm versus 5,33-14 μm ; p=0,0005) on 10 minutes after surgery and 0 μm versus 0,33-4 μm ; p=0,0005 on day-7 after surgery. In conclusion, the graft attachment using albumen glue was better and the wound gap was smaller using albumen glue than suture technique.